Visible-Light-Mediated Z-Stereoselective Monoalkylation of β,β-Dichlorostyrenes by Photoredox/Nickel Dual Catalysis

Abstract Metal-catalyzed alkylation of 1,1-dihalovinyl moiety commonly suffers from both a lack stereoselectivity and the overreaction leading to dialkylation product. The methodology described herein features new pathway alkylate stereoselectively β,β-dichlorostyryl substrates provide Z-trisubstituted olefin only with fair good yields. This cross-coupling reaction bears on smooth photoinduced formation C-centered radical that engages in nickel-catalyzed organometallic cycle form key Csp2–Csp3 bond.